The community is exploring the idea that omega-3 fatty acids might reduce the accumulation of advanced glycation end-products (AGEs), those compounds linked to cellular aging, suggesting a protective effect against systemic inflammation.

noli's read

The link between omega-3s and AGE reduction rests on plausible theoretical mechanisms, notably via their well-documented anti-inflammatory properties. Meta-analyses (e.g., Gammone et al., 2019) confirm that omega-3s (EPA/DHA) improve inflammatory markers and cardiometabolic health, which could indirectly limit AGE-related damage. However, the claim that they act directly as specific AGE modulators in humans remains largely speculative and requires more rigorous clinical trials (RCTs) to be validated. The idea of 'frying in fish oil' is a humorous and erroneous extrapolation, as intense heat degrades these fragile fatty acids. Finally, the question about glycine shows confusion regarding molecular mechanisms, as glycine is a precursor to potentially protective glutathione rather than a factor promoting AGEs. The community is in a phase of curious inquiry rather than established consensus.

the sources

1. 1r/ScientificNutrition