The community rejects the idea that regular aspartame consumption is toxic to the liver or fertility, noting that alarmist studies on rodents use massive doses unattainable in a normal human diet.

noli's read

The debate centers on the relevance of animal studies to actual human use. The toxicological research cited uses doses of 100 mg/kg, which would be equivalent to several dozen cans of soda per day for an adult, an amount that far exceeds the acceptable daily intakes defined by health authorities (JECFA, EFSA). While studies on rats observe oxidative stress at very high doses, these results cannot be directly extrapolated to humans due to major metabolic differences and the volumes consumed. There is no solid clinical evidence establishing hepatic or reproductive toxicity at usual doses. Interest in the antioxidant role of N-acetylcysteine (NAC) and vitamin C is mentioned, but remains disconnected from the question of aspartame's actual safety. The community strongly converges toward skepticism regarding the extrapolation of these experimental results to daily life.

the sources

1. 1r/ScientificNutrition