Siim Land proposes a list of longevity supplements including taurine, collagen, glycine and NAC (GlyNAC), berberine, omega-3s, magnesium, and TMG.

noli's read

The majority of these ingredients are based on promising biological mechanisms, but the level of evidence varies. GlyNAC has shown improvement in markers of aging and oxidative stress in randomized clinical trials (RCTs) in older adults. Collagen has strong support via meta-analyses for skin hydration and elasticity. Berberine is recognized for its effects on glucose and lipids, validated by meta-analyses, although its use as a longevity pill remains theoretical. Omega-3s have mixed evidence: while their benefit for cardiovascular and inflammatory health is supported, recent studies temper their direct protective effect on cognitive decline. Magnesium is essential for many functions, with observational evidence linking higher intake to better brain health. Taurine and TMG are active subjects: taurine has shown lifespan extension in animals, but clinical human evidence regarding longevity remains limited, as does TMG, which is often used as a supplement to support metabolism.

the sources

1. 1NIH Office of Dietary Supplements 2026
2. 2Manson JE et al. 2019
3. 3Bhatt DL et al. 2019
4. 4NIH Office of Dietary Supplements 2026