You should not buy NAD+ supplements in the hope of relieving menopause symptoms (hot flashes, sleep issues), as there is currently no solid scientific evidence (such as a placebo-controlled clinical trial) validating their efficacy.

noli's read

The creator's position is scientifically very accurate and faithfully describes the current state of research. The rigorous study she mentions, published in the journal Science by Yoshino et al. (2021)—a randomized controlled trial (RCT)—clearly shows that an NAD+ precursor improves muscle insulin sensitivity in postmenopausal, prediabetic women, but it did not measure general well-being, sleep, or hot flashes. Regarding these latter aspects, research is limited to very short pilot studies without a control group, which is more akin to a placebo effect than genuine proof of efficacy. Experts agree that while NAD+ is an exciting avenue for cellular vitality, clinical data are lacking to make it a ritual focused on menopause comfort. The creator's field observation, which qualifies as expert opinion, confirms this absence of tangible results in her patients. Following her recommendation to wait for stronger evidence before investing in these molecules is therefore a very wise approach.

the sources

1. 1Martens CR, Denman BA, Mazzo MR, et al. 2018
2. 2Elhassan YS, Kluckova K, Fletcher RS, et al. 2019