Mary Claire Haver, MD@drmaryclaireInstagram

Rating my deepfakes. This one stole my face and my voice to sell you an NAD+ supplement for menopause. So

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what it claims

Do not purchase NAD+ supplements in the hope of alleviating menopause-related discomforts (hot flashes, energy dips, sleep disturbances), as solid and rigorous scientific evidence is currently lacking.

holds up

Mary Claire Haver is entirely correct to highlight the limitations of the 2026 pilot study published in *Frontiers in Aging* by Holmes and his team.

noli's read

Mary Claire Haver is entirely correct to highlight the limitations of the 2026 pilot study published in *Frontiers in Aging* by Holmes and his team. This open-label clinical trial, conducted on only 40 women for 7 days, indeed presents a high risk of bias due to the absence of a placebo group. Regarding the second study published in the journal *Science* by Yoshino and his collaborators (2021), it is indeed a rigorous randomized controlled trial (RCT). However, this work focused on the metabolic sphere by demonstrating an improvement in insulin sensitivity in postmenopausal women, without ever evaluating the classic physical or cognitive discomforts of the hormonal transition. Currently, no robust double-blind trial confirms the impact of NAD+ precursors on sleep, temperature variations, or mental clarity. Although research on cellular vitality is fascinating, the effectiveness of these molecules for daily hormonal well-being currently rests only on theoretical assumptions and isolated clinical observations.

the sources

Claimed by Mary Claire Haver, MD. Noli grades the claim, never the person.

Decoded by Noli · July 13, 2026 · the original post

What the graded evidence says

Evidence: D

Effect: blood/muscle NAD+ metabolome vs. clinical outcomes (function, metabolism, longevity) — NR ~1000 mg/day raised NAD+ ~60% in healthy older adults (Martens, n=24 crossover) and augmented the aged muscle NAD+ metabolome (Elhassan, n=12) — but with only exploratory signals (a modest blood-pressure hint; anti-inflammatory cytokine shifts) and no proven functional or longevity benefit. No RCT evidence for hair/nail growth.
Measured on: healthy middle-aged and older adults; small trials (n=12-24), short duration

These raise NAD+ convincingly; the leap from 'higher NAD+' to 'you age slower or feel better' is unproven in humans. Longevity, energy and hair/nail claims are marketing ahead of the evidence.

Mary Claire Haver, MD in the Register58 claims graded · solidity 89/100See their record →