Taking 5 grams of creatine with 1 gram of glucose per day for 56 days reduces total cholesterol, triglycerides, and VLDL in people with high cholesterol levels.

noli's read

This advice is based on a 1996 randomized controlled trial (RCT) by Earnest et al., which did indeed observe these encouraging reductions in a small group of participants. However, the overall body of science today calls for significant nuance. A recent meta-analysis, published in 2026 by Gimenez and his team in the journal Frontiers in Nutrition, compiled the results of 8 controlled clinical trials. The authors concluded that creatine supplementation does not lead to any overall significant improvement in circulating fats or cholesterol. Although creatine excels for cellular energy and physical fitness, its lipid-regulating virtues are not validated by the entirety of current data. It is therefore an exaggeration to promote this specific protocol as a solution for optimizing your lipid markers.

the sources

1. 1NIH Office of Dietary Supplements 2026
2. 2Manson JE et al. 2019
3. 3foundmyfitness.com/topics