Siim Land suggests the daily intake of five supplements after the age of 60: Glycine and NAC (for declining antioxidant defenses), Melatonin (to compensate for reduced natural production), Creatine (for muscle and brain function), and Nattokinase (for blood coagulation management).

noli's read

The advice regarding the Glycine+NAC (GlyNAC) combination is supported by randomized clinical trials (e.g., Baylor College of Medicine) showing an improvement in antioxidant status and muscle strength in older individuals. Creatine is widely validated by numerous studies (meta-analyses) for preserving muscle mass and supporting cognitive functions as one ages. Regarding melatonin, the evidence is mixed: while it aids sleep and possesses antioxidant properties, its long-term use in seniors remains less documented and should be considered with caution. Nattokinase is the subject of promising preliminary studies on coagulation and blood pressure, but robust clinical evidence remains limited compared to the other molecules mentioned. Finally, it is important to note that any impact on coagulation can interact with medical treatments, making supervision necessary. These supplements are presented as strategic tools to support a solid foundation of lifestyle habits rather than as a miracle solution.

the sources

1. 1NIH Office of Dietary Supplements 2026