Engaging in brief but intense physical activity (only 4 minutes per day) stimulates the release of beneficial molecules from our muscles (myokines, such as IL-6), reducing internal inflammation and promoting longevity.

noli's read

This perspective views muscle as a dynamic organ that releases myokines, which are essential messengers for bodily balance. The work of researcher Bente Klarlund Pedersen (expert reviews) confirms that interleukin-6 (IL-6) released by muscle during exertion helps to positively regulate internal inflammatory responses. Regarding longevity, the large-scale observational study led by Stamatakis and colleagues (Nature Medicine, 2022) demonstrates that only 3 to 4 minutes per day of vigorous, short-duration physical exertion reduces the risk of premature death by nearly 30%. Concerning strengthening, the clinical trial by Maria Fiatarone (JAMA, 1990) confirms in a dramatic way that an 8-week resistance program enabled 90-year-old seniors to increase their average strength by 174%. Finally, the abandonment by GlaxoSmithKline in 2007 of the molecule GW501516 ("exercise in a pill") following tumors observed during preclinical studies highlights the limitations of an artificial shortcut. Although the data on longevity are derived from observations rather than absolute causality, the arguments put forward by Dr.Noc are based on a foundation of excellent scientific rigor.

the sources

1. 1Hoffmann C, Weigert C 2017
2. 2Stamatakis E et al. 2022
3. 3Stamatakis E et al. 2023