Actively contracting your muscles releases protective messengers (myokines) that optimize the body and stimulate brain plasticity, with as little as 4 minutes of intense effort per day being sufficient to significantly boost longevity.

noli's read

The concept of muscle as a source of beneficial molecules is solidly validated by scientific research. The regulatory role of IL-6 released during exercise was described by researchers Petersen and Pedersen (2005, narrative review), showing how movement helps to harmonize the body. The link between the CTSB protein, mental tone, and cerebral regeneration is based on a landmark study published in *Cell Metabolism* (Moon et al., 2016) that combines observations in humans with tests on animal models. Nevertheless, while the creation of new cerebral connections stimulated by this protein is proven in animals, it remains complex to measure directly in humans and is primarily a matter of correlation. Finally, the benefit of 4 minutes of daily vigor comes from a large observational study (Stamatakis et al., 2022, *Nature Medicine*), which reveals a promising association with longevity without, however, constituting absolute clinical proof of cause and effect.

the sources

1. 1Hoffmann C, Weigert C 2017
2. 2Stamatakis E et al. 2022
3. 3Stamatakis E et al. 2023