Creatine supplementation increases brain creatine stores, which may improve working memory and cognitive function, especially under conditions of metabolic stress such as sleep deprivation, a vegetarian diet, or neurodegenerative diseases.

noli's read

Research does indeed support that the brain utilizes creatine for cellular energy maintenance, and several studies confirm that supplementation can increase these brain stores (Meta-analysis, Avgerinos et al., 2018). The effect on working memory is documented in contexts of fatigue or cognitive stress, where energy demands are higher (RCT, Rae et al., 2003). It is scientifically accurate that vegetarians, whose dietary intake is naturally lower, often observe more pronounced benefits. The claim regarding neurodegenerative diseases is promising but remains largely at the stage of clinical exploration (observational studies and preliminary trials). There is no major exaggeration here, as Rhonda Patrick carefully nuances her statements by targeting specific subgroups rather than generalizing a miracle effect for everyone. The current scientific consensus validates the mechanism, even if the extent of the benefits in healthy, well-rested individuals still requires further investigation.

the sources

1. 1NIH Office of Dietary Supplements 2026
2. 2Manson JE et al. 2019
3. 3foundmyfitness.com/topics