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Mark Hyman, M.D.@drmarkhymanInstagram

As you get older, your body becomes more resistant to using protein efficiently — which means you actually

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what it claims

With age, and particularly for women over 40, the body becomes less sensitive to protein assimilation; it is therefore recommended to increase daily intake (between 1.8 and 2.2 g per kilogram of body weight) and to consume 35 to 40 g of protein per meal to effectively activate muscle regeneration.

mixed

The phenomenon of decreased sensitivity to protein assimilation with age (anabolic resistance) is widely validated by research, notably by the recommendations of the PROT-AGE…

noli's read

The phenomenon of decreased sensitivity to protein assimilation with age (anabolic resistance) is widely validated by research, notably by the recommendations of the PROT-AGE international study group. Reaching 35 to 40 g of protein per meal is a strategy supported by randomized controlled trials (RCTs) to cross the amino acid threshold necessary for maintaining muscle mass. However, the suggested total daily intake (1.8 to 2.2 g/kg) is at the very high end of the International Society of Sports Nutrition (ISSN) range, whereas guidelines for active mature adults typically target 1.2 to 1.5 g/kg instead. Finally, the assertion that women experience greater anabolic resistance than men is based on metabolic studies (such as observational work from the University of Nottingham linked to the natural decline in estrogen), even though both sexes receive similar attention regarding their intake. As for a small protein snack before exercise, it remains a relevant practical tip, although its effects compared to a full meal are still a subject of discussion.

the sources

  1. 1Morton RW, Murphy KT, McKellar SR, et al. 2018
  2. 2Leidy HJ, Clifton PM, Astrup A, et al. 2015

Claimed by Mark Hyman, M.D. Noli grades the claim, never the person.

Decoded by Noli · July 13, 2026 · the original post

What the graded evidence says

Evidence
B+
Effect
fat-free mass gain (resistance training) and appetite/satiety — +0.30 kg fat-free mass with protein supplementation (95% CI 0.09-0.52), plateau at ~1.62 g/kg/day; higher protein meals reliably increase satiety vs equal-calorie lower-protein meals
Measured on
healthy training adults; weight-loss and weight-maintenance adults

What’s uncertain

More protein past roughly 1.6 g/kg/day doesn't add much for muscle or fullness. The satiety edge is real but modest, not a magic appetite switch.

Mark Hyman, M.D. in the Register140 claims graded · solidity 73/100See their record →

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