To slow epigenetic aging, it is necessary to practice vigorous physical activity, as light to moderate activities are not sufficient.

noli's read

Scientific research does indeed suggest a positive correlation between exercise intensity and the preservation of the biological clock (epigenetic clocks). A study published in the Journal of Applied Physiology (2024), which seems to correspond to David Sinclair's reference, indicates that individuals with high vigorous activity exhibit a biological age lower than their chronological age compared to sedentary individuals or moderate exercisers. However, labeling light or moderate activities as 'not sufficient' is a strong interpretation. Existing literature, particularly meta-analyses on physical activity and metabolic health, shows that moderate activity already offers immense protective benefits for cardiovascular health and longevity, even if vigorous intensity appears to further optimize specific epigenetic markers. It is therefore more accurate to say that vigorous intensity is a powerful lever rather than to discredit moderate efforts. Science supports the link, but the nuance lies in the fact that any movement remains beneficial for overall health.

the sources

1. 1Milanović Z, Sporiš G, Weston M 2015
2. 2Stamatakis E et al. 2022
3. 3Stamatakis E et al. 2023