To optimize learning and neuroplasticity, you should aim for an error rate of approximately 15% during practice, which corresponds to a success rate of 85%.

holds up

This concept is based on a study published in 'Nature Communications' (Wilson et al., 2019), which used machine learning models to test different difficulty rates.

noli's read

This concept is based on a study published in 'Nature Communications' (Wilson et al., 2019), which used machine learning models to test different difficulty rates. The researchers concluded that the 'sweet spot' for rapid learning is indeed around an error rate of 15.87%. This is a robust computational and behavioral study that supports the idea that if a task is too easy, neural change is not sufficiently stimulated, and if it is too difficult, the learning process stalls. Its application to human learning is consistent with the principles of cognitive psychology, notably 'desirable difficulty.' However, it is important to note that this 15% figure is a theoretical mathematical estimate and not an absolute universal rule for every individual or every skill. The analysis is therefore scientifically grounded, although its concrete application in daily life requires a certain degree of flexibility.

the sources

Claimed by Andrew Huberman. Noli grades the claim, never the person.

Decoded by Noli · July 18, 2026 · the original post

What the graded evidence says

Effect: CV events, high-risk patients on high-dose EPA (REDUCE-IT) — -25% relative (high-risk only)
Measured on: REDUCE-IT: 8,179 statin-treated high-risk patients

Strong for a specific medical use; modest for everyday wellness.

Noli has read similar claims

Other advice in the Register that leans on the same research.

To support heart, brain, and immune system health, it is recommended to use a high-quality omega-3 supplement (with transparent purity testing) to compensate for insufficient intake in the modern diet.

holds upSteph Grasso, MS, RD

Get your vitamin D and triglyceride levels tested at the onset of menopause, as the drop in estrogen naturally increases cardiovascular risk. To address this, it is recommended to supplement with vitamin D, vitamin K2 (to guide calcium toward the bones rather than the arteries), and 2g of EPA-rich omega-3s to limit inflammation and regulate blood lipids.

holds upMary Claire Haver, MD

Omega-3s (especially in EPA/DHA forms) are essential fats often lacking in our modern diet. Supplementing allows, in a scientifically proven manner but without miracles, for the reduction of inflammatory stress, the acceleration of physical recovery, the support of cardiac vitality, and the stabilization of mood.

holds upGreg /Major Mouvement ( kiné à bretelles )

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