Take 400 mg of Tongkat Ali daily, ideally in the morning, to reduce SHBG (sex hormone-binding globulin) and thereby optimize testosterone levels.

mixed

Tongkat Ali (Eurycoma longifolia) is studied for its potential to support hormonal balance.

noli's read

Tongkat Ali (Eurycoma longifolia) is studied for its potential to support hormonal balance. Research does indeed show evidence that this plant can reduce SHBG and increase free testosterone, particularly in individuals experiencing chronic stress or those with initially low levels (meta-analysis, PubMed). However, the idea that it is a universal 'optimizer' for everyone is an extrapolation; effects in young, healthy men are less pronounced and long-term data remain limited (observational studies and small-scale RCTs). The claim regarding timing (morning) is primarily based on theoretical mechanisms linked to circadian rhythm rather than direct clinical evidence comparing different times of ingestion. It is important to note that the quality of supplements on the market is highly variable, which can influence perceived results. In summary, while the biological mechanism is documented, the magnitude of the effect in a general wellness context is often presented more robustly than current scientific literature confirms.

the sources

Claimed by Andrew Huberman. Noli grades the claim, never the person.

Decoded by Noli · July 18, 2026 · the original post

What the graded evidence says

Effect: CV events, high-risk patients on high-dose EPA (REDUCE-IT) — -25% relative (high-risk only)
Measured on: REDUCE-IT: 8,179 statin-treated high-risk patients

Strong for a specific medical use; modest for everyday wellness.

Noli has read similar claims

Other advice in the Register that leans on the same research.

To support heart, brain, and immune system health, it is recommended to use a high-quality omega-3 supplement (with transparent purity testing) to compensate for insufficient intake in the modern diet.

holds upSteph Grasso, MS, RD

Get your vitamin D and triglyceride levels tested at the onset of menopause, as the drop in estrogen naturally increases cardiovascular risk. To address this, it is recommended to supplement with vitamin D, vitamin K2 (to guide calcium toward the bones rather than the arteries), and 2g of EPA-rich omega-3s to limit inflammation and regulate blood lipids.

holds upMary Claire Haver, MD

Omega-3s (especially in EPA/DHA forms) are essential fats often lacking in our modern diet. Supplementing allows, in a scientifically proven manner but without miracles, for the reduction of inflammatory stress, the acceleration of physical recovery, the support of cardiac vitality, and the stabilization of mood.

holds upGreg /Major Mouvement ( kiné à bretelles )

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