Subcutaneous injection of unregulated growth factors can lead to severe facial deformities and the formation of persistent masses (known as 'bubble face') in the long term.

noli's read

Dr. Youn warns against the off-label use of injectable growth factors, a practice documented as risky in certain unregulated clinical contexts. Research confirms, notably via a study published in *Aesthetic Plastic Surgery* (observational study/case series), that these injections can cause granulomas or lipoma-like masses, for which the recurrence rate is significant after excision. While the topical or localized use of growth factors is validated in wound healing, their direct injection for aesthetic purposes outside a strict medical framework lacks long-term safety evidence. The creator clearly distinguishes between approved products (Botox, hyaluronic acid, autologous tissues) and experimental or illegal substances. His analysis is consistent with existing literature on complications linked to unidentified or misused fillers. There is no notable exaggeration here, as this is a warning regarding potentially dangerous off-label practices.

the sources

No named source held this one up — that absence is part of the verdict.