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Siim Land@siimlandX

Health biomarker cheat sheet: 1️⃣VO2 max: cardiorespiratory fitness 2️⃣HRV: autonomic nervous system balance, cardiac function 3️⃣hsCRP

what it claims

Siim Land suggests that a specific list of biomarkers (VO2 max, HRV, hsCRP, ApoB, eGFR, HbA1c) serves as an essential 'cheat sheet' for assessing and tracking one's overall health.

holds up

This selection is highly relevant and aligned with modern preventive medicine. VO2 max is recognized as one of the most powerful predictors of longevity (meta-analysis, JAMA).

noli's read

This selection is highly relevant and aligned with modern preventive medicine. VO2 max is recognized as one of the most powerful predictors of longevity (meta-analysis, JAMA). HRV is a validated indicator of nervous system resilience to stress (observational studies). hsCRP is the standard marker for low-grade systemic inflammation, well-established for monitoring cardiovascular risk. ApoB is considered by many researchers to be a more precise marker of atherogenic risk than conventional LDL cholesterol (prospective studies). eGFR and HbA1c are the gold standards for monitoring renal function and long-term glycemic control, respectively. The only caveat is the notion of a 'cheat sheet': these markers are not isolated measurements but must be interpreted by a professional within the individual's overall context to avoid unnecessary anxiety over benign fluctuations.

the sources

  1. 1Mandsager K, Harb S, Cremer P, Phelan D, Nissen SE, Jaber W 2018

Claimed by Siim Land. Noli grades the claim, never the person.

Decoded by Noli · July 18, 2026 · the original post

What the graded evidence says

Evidence
B

Linked to, not proven to cause.

Effect
all-cause mortality by cardiorespiratory fitness (treadmill METs) — elite vs low fitness adjusted HR 0.20 (95% CI 0.16-0.24); mortality inversely proportional to fitness with no upper limit of benefit; n=122,007
Measured on
adults referred for exercise treadmill testing (single large health system)

What’s uncertain

The fitness-mortality link is observational and drawn from patients referred for treadmill testing, so it shows strong association, not proof of cause. Dramatic comparisons (e.g. 'more dangerous than smoking') are rhetorical, not precise.

Siim Land in the Register50 claims graded · solidity 79/100See their record →

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