Nicotinamide riboside (NR) supplementation in humans shows very few clinically relevant effects, particularly regarding metabolism.

noli's read

This assessment by Brad Stanfield aligns with a critical review of current scientific literature. Although several studies confirm that NR is an effective precursor for increasing NAD+ levels in the blood, there is a significant gap between this biological increase and concrete benefits for human health. Numerous research studies, including randomized controlled trials (RCTs) and systematic reviews, indicate that NR does not produce significant improvements in insulin sensitivity, mitochondrial function, or body composition in adults. While some preliminary results suggest effects on inflammation or very specific markers in restricted populations, the idea that NR can transform metabolism or general health remains, to date, clinically unproven. Initial enthusiasm, often stemming from studies on animal models, is tempered by more nuanced and often disappointing human results.

the sources

1. 1Martens CR, Denman BA, Mazzo MR, et al. 2018
2. 2Elhassan YS, Kluckova K, Fletcher RS, et al. 2019