NAD is a key longevity molecule whose levels decline with age, thereby accelerating aging; it is therefore crucial to optimize its natural production and minimize its loss.

noli's read

The idea that NAD (nicotinamide adenine dinucleotide) plays a central role in cellular metabolism and aging is widely supported by preclinical research (animal models and cellular studies), as shown by the work of David Sinclair and other researchers. It is established that NAD levels do indeed decrease with age in mammals, which affects mitochondrial function. However, it is important to note that the majority of evidence concerning the reversal of aging via NAD precursors (such as NMN or NR) comes from animal studies, with more nuanced results in humans. While clinical trials (RCT) have confirmed that supplementation can increase circulating NAD levels, the direct impact on human longevity is not yet demonstrated. The approach of maximizing natural production (via exercise or fasting) is based on plausible biological mechanisms like sirtuin activation, but remains largely exploratory. There is therefore a significant gap between the fascinating biological mechanisms identified in the laboratory and concrete application advice for long-term human health.

the sources

1. 1Martens CR, Denman BA, Mazzo MR, et al. 2018
2. 2Elhassan YS, Kluckova K, Fletcher RS, et al. 2019