Dr. Mike Israetel suggests here that the use of peptides is a relevant lever or a central topic of discussion for fat loss and body composition.

noli's read

The use of peptides (such as GLP-1 analogs or growth hormone secretagogues) for weight loss is the subject of growing research interest. Meta-analyses on GLP-1 receptor agonists (e.g., semaglutide) confirm robust efficacy for weight loss by regulating appetite, often classified as high-level evidence (RCTs). However, the use of peptides in a general fitness context remains a gray area: many substances promoted in this field lack long-term clinical trials in healthy subjects. While some peptides show real metabolic potential, their framework for use remains strictly medical and not that of an innocuous dietary supplement. The scientific discourse emphasizes that these tools do not replace the fundamentals (caloric deficit, protein, physical activity) but rather act as facilitators. It is crucial to distinguish validated pharmaceutical products from 'unregulated' peptides sold online, whose purity and efficacy are often uncertain.

the sources

1. 1Wilding JPH et al. (STEP 1) 2021
2. 2Jastreboff AM et al. (SURMOUNT-1) 2022
3. 3Jastreboff AM et al. 2023
4. 4Wilding JPH et al. (STEP 1 extension) 2022