Circadian clock dysfunction is a key marker of aging, characterized by a flattening and dysregulation of natural biological rhythms with age.

noli's read

The scientific evidence largely supports this assertion: specialized literature in geroscience identifies the decline in the robustness of circadian rhythms as a central element of aging (scientific reviews, observational consensus). With age, we effectively observe a reduction in the amplitude of biological fluctuations—such as body temperature, melatonin secretion, or cortisol—which makes internal signals less distinct. This phenomenon is linked to numerous processes of cellular and metabolic degradation. While the link is strong, referring to it as a 'signature' or 'marker' is more precise than designating it as the sole cause of aging, as it is a complex, bidirectional relationship: aging degrades the clock, and a dysregulated clock accelerates the signs of aging. Therefore, there is no exaggeration in the importance attributed to the subject, even if the exact molecular mechanisms are still the subject of active research.

the sources

No named source held this one up — that absence is part of the verdict.