noli.

Register

Mark Hyman, M.D.@drmarkhymanX

Did you know cuddling or being in a loving relationship can literally change your gene expression? It activates repair genes and turns off

what it claims

Being in a romantic relationship or engaging in physical contact (hugging) can alter your gene expression by activating repair genes and deactivating inflammation.

mixed

This claim is based on the emerging field of psychobiology and social epigenetics.

noli's read

This claim is based on the emerging field of psychobiology and social epigenetics. Studies, particularly those published in *Psychoneuroendocrinology* (observational and interventional studies), show that social support and positive relationships influence inflammatory markers like C-reactive protein (CRP) and the expression of genes related to the immune response. It is well-established that chronic stress activates pro-inflammatory genes (CTRA response), and that soothing interactions can modulate this response. However, the use of the term 'alter your gene expression' is scientifically accurate but often misinterpreted as a permanent or magical transformation. In reality, these are dynamic and reversible regulations dependent on the environment, not a fundamental reprogramming of DNA. The idea that love is 'medicine' is a powerful metaphorical simplification that reflects the real impact of social ties on stress biology, although it does not replace medical treatments for confirmed inflammatory conditions.

the sources

  1. 1Holt-Lunstad J, Smith TB, Layton JB. 2010
  2. 2Holt-Lunstad J, Smith TB, Baker M, et al. 2015

Claimed by Mark Hyman, M.D. Noli grades the claim, never the person.

Decoded by Noli · July 18, 2026 · the original post

What the graded evidence says

Evidence
B+

Linked to, not proven to cause.

Effect
survival by strength of social relationships; mortality risk from loneliness/social isolation/living alone (meta-analyses of cohorts) — stronger social relationships OR 1.50 (95% CI 1.42-1.59) for survival; social isolation OR 1.29, loneliness OR 1.26, living alone OR 1.32 for mortality
Measured on
adults across many countries and age groups (308,849+ participants pooled)

What’s uncertain

These are associations from cohort studies, so healthier, better-resourced people may both connect more and live longer. The link is strong and consistent, but claims that touch or connection directly "change your gene expression" go beyond the evidence.

Mark Hyman, M.D. in the Register140 claims graded · solidity 73/100See their record →

More from Mark Hyman, M.D.

Noli has read similar claims

Other advice in the Register that leans on the same research.

Noli, a firefly holding its lantern, at rest

Seen something like this? Send it to Noli.

Paste any health post from TikTok, Instagram, YouTube or X — or the advice itself, if someone just told you. About ten seconds, no account needed.