Vigorous exercise induces the production of muscle lactate, which crosses the blood-brain barrier to stimulate the production of BDNF in the brain, acting as an essential growth factor for brain health.

noli's read

Science strongly supports the link between physical exercise and increased BDNF (Brain-Derived Neurotrophic Factor), a key protein for neuronal plasticity. A landmark study published in *Cell Metabolism* (2019) indeed demonstrated that lactate, produced during intense effort, can cross the blood-brain barrier in mice and promote BDNF expression, confirming a metabolic signaling mechanism. Meta-analyses in humans also confirm that intense exercise is particularly effective at stimulating circulating BDNF levels compared to moderate exercise. The "youth elixir" analogy is a figurative simplification, although BDNF plays a crucial role in maintaining cognitive functions and neuronal survival. It is important to note that while the role of lactate is promising, other factors such as myokines or increased cerebral blood flow also contribute to this complex response. The mechanism is therefore widely supported by current research, although the exact transposition from animal models to humans remains an active area of study.

the sources

1. 1Hoffmann C, Weigert C 2017