There is reportedly a target estradiol level of approximately 60 pg/mL in the blood to protect the heart and bones of postmenopausal women. The most common hormone therapy patches are said to achieve this level, suggesting the benefit of measuring this rate via blood test to optimize long-term well-being.

noli's read

The creator relies on a very recent study by Piette and Simon published in Gynecological Endocrinology (July 2026), which models data to propose this target of 60 pg/mL to optimize bone and cardiovascular well-being. This analysis is based on a comparison with large randomized clinical trials (the KEEPS and ELITE trials), showing that the observed benefits often coincide with this blood concentration level. However, this is a theoretical extrapolation and not new direct evidence that routine blood monitoring improves longevity. Current scientific consensus does not recommend measuring estradiol to adjust hormone therapy, as these levels fluctuate naturally and evaluation is primarily based on symptoms. Furthermore, the use of these hormones for purely preventive purposes for the heart has not yet been validated by health authorities. The creator herself judiciously nuances her statement by speaking of a 'signal' rather than an official recommendation, which is scientifically rigorous.

the sources

No named source held this one up — that absence is part of the verdict.