The practice of extremely intense physical exercise could temporarily impair intellectual capabilities due to specific muscular metabolic mechanisms.

noli's read

The thread discusses a recent study suggesting that very vigorous physical exertion causes the accumulation of lactate, stimulating the secretion of mitochondrial-derived vesicles (otMDVs) by muscles, which could disrupt energy at the synapses. This biological mechanism identified by the researchers constitutes an intriguing mechanistic lead but requires cautious interpretation, as current evidence stems primarily from experimental models (fundamental research) rather than long-term clinical trials in humans. It is common and scientifically documented that acute physical exhaustion temporarily reduces mental clarity, often due to central nervous system fatigue rather than this specific metabolic pathway. The idea that intense exercise is globally harmful is, however, exaggerated, as scientific literature (meta-analyses and systematic reviews) overwhelmingly highlights the long-term benefits of physical activity, including intense exercise, for brain health and neuroplasticity. The forum community shows a convergence on the fact that this phenomenon is transient and linked to immediate intensity, without calling into question the general utility of sports.

the sources

1. 1r/AdvancedFitness