The Interventions Testing Program (ITP) recently published results showing that Alpha-ketoglutarate, 2,4-Dinitrophenol, Hydralazine, and Sodium thiosulfate have no effect on lifespan, while 16α-Hydroxyestriol and Canagliflozin show sex-dependent effects (beneficial in males, neutral or negative in females).

noli's read

The cited report indeed originates from the National Institute on Aging (NIA) Interventions Testing Program, a robust benchmark in preclinical longevity research using standardized mouse models. The data effectively confirm the absence of a significant effect for the first four substances mentioned under these specific conditions. Regarding Canagliflozin, an antidiabetic drug in the SGLT2 inhibitor class, ITP results indicate an extension of lifespan in male mice, but not in females, which illustrates significant sexual dimorphism. A potential exaggeration to avoid would be to extrapolate these mouse longevity results directly to humans or to daily preventative supplementation. 16α-Hydroxyestriol is an estrogenic metabolite whose observed effects remain purely experimental. It is crucial to note that these studies serve to identify biological leads and not to prescribe wellness protocols for the general public.

the sources

No named source held this one up — that absence is part of the verdict.