Regular physical exercise, particularly muscle strengthening and VO2 max improvement, constitutes the most powerful tool for increasing longevity.

noli's read

Peter Attia relies on a robust scientific literature that directly correlates cardiorespiratory fitness (VO2 max) and muscle strength with a significant reduction in all-cause mortality. Major meta-analyses (notably published in the British Journal of Sports Medicine) confirm that muscle strength is an independent predictor of longevity, while VO2 max is widely considered one of the most powerful biomarkers of long-term health. The analogy to a "drug" is a common rhetorical metaphor to highlight the scale of metabolic and systemic benefits, which often exceed those of many pharmacological interventions. There is no scientific exaggeration here, as the observational evidence is vast and convergent. The consensus is clear: maintaining these physical capacities is essential for preventing age-related decline (sarcopenia and metabolic frailty).

the sources

1. 1Wu Y, Wang W, Liu T, Zhang D 2017
2. 2Li R, Xia J, Zhang X, et al. 2018
3. 3Mandsager K, Harb S, Cremer P, Phelan D, Nissen SE, Jaber W 2018