Rapid weight loss, whether resulting from highly restrictive diets or the use of weight-loss aids (such as GLP-1 analogues), harms our bone strength, which ultimately compromises our independence, physical fitness, and longevity.

noli's read

Research widely confirms that any rapid weight loss is accompanied by a decrease in bone strength, a phenomenon documented by numerous observational and clinical studies. A systematic review of clinical trials published by the American Osteopathic Association (AOAO, 2026) shows that the use of GLP-1 molecules causes a reduction in bone mass similar to that of extreme caloric restriction. Bone health specialists, such as Dr. Wendy Kohrt of the University of Colorado (expert opinion), warn that this weakening is critical for women approaching menopause, increasing the risk of falls and injuries. Furthermore, large observational studies directly associate fractures at an advanced age with a loss of independence and a decline in life expectancy, which validates the direct connection established with longevity. Although the specific biological impact of these molecules is still the subject of research and debate, rapid weight loss deprives our bones of the physical stimulation necessary for their renewal. Thus, the recommendation to accompany any weight-loss regimen with resistance exercises and key nutrients (protein, calcium, vitamin D) is scientifically essential to protect one's future well-being.

the sources

1. 1Wilding JPH et al. (STEP 1) 2021
2. 2Jastreboff AM et al. (SURMOUNT-1) 2022
3. 3Jastreboff AM et al. 2023
4. 4Wilding JPH et al. (STEP 1 extension) 2022