Preliminary results suggest that psilocybin could extend lifespan, but it is too early to state that this applies to human aging.

noli's read

The statement is based on a 2025 study (Kato et al., published in NPJ Aging) showing that psilocin, a metabolite of psilocybin, extends the lifespan of human cells in culture and increases survival in aged mice. This work observes a reduction in oxidative stress, preservation of telomeres, and activation of longevity-related genes such as SIRT1. However, Peter Attia correctly points out that this evidence is limited to cellular and animal models. There is currently no clinical data demonstrating a similar effect on human life expectancy. Comparisons based on observations of individuals who have consumed psychedelics do not allow for the conclusion of a causal benefit, given socio-economic biases.

the sources

No named source held this one up — that absence is part of the verdict.