Low-grade inflammation and obesity hinder muscle growth; it is therefore essential to prioritize body composition to foster positive results.

noli's read

The analysis of the cited study (PMID: 31263701, a narrative review) confirms that obesity induces a state of chronic systemic inflammation that can effectively impair anabolic signaling and the muscle response to exercise. Research indicates that this metabolic environment renders muscle tissue more resistant to growth stimuli, a phenomenon sometimes referred to as 'anabolic resistance.' It is scientifically accurate to state that managing body composition is a relevant strategy for optimizing metabolic and muscular health. However, the term 'hinder' remains a simplification of a complex process: muscle can still adapt, but the efficiency of the process is reduced. The approach is consistent with current knowledge on the interaction between adipose tissue and muscle tissue. This is not an impossibility, but rather a less favorable biological context that requires increased attention to nutrition and physical activity.

the sources

No named source held this one up — that absence is part of the verdict.