Insulin resistance in skeletal muscle appears more than a decade before the pancreas weakens and fasting blood glucose actually rises.

noli's read

This advice is based on a solid understanding of metabolic pathophysiology. Research, notably the cited study (PMID: 19875544, a scientific review), confirms that skeletal muscle is the primary site of postprandial glucose disposal and that its insulin resistance is often an early event. Observational and mechanistic data support the idea that the body compensates for this initial resistance through hyperinsulinemia, thereby masking the problem on standard blood glucose tests for a long period. The statement is scientifically consistent, although the precise timeline of "more than a decade" can vary considerably from one individual to another depending on lifestyle and genetics. It is not an absolute generality, but a credible temporal marker in the development of metabolic dysfunction. The strong point here is highlighting that fasting blood glucose is a late indicator, which is validated by current scientific literature.

the sources

No named source held this one up — that absence is part of the verdict.