High daily caffeine consumption could hinder muscle building and connective tissue strength, thereby counteracting the long-term benefits of physical training.

noli's read

The thread shows a skeptical community that favors caution regarding a study conducted on cell and murine models. Scientifically, the evidence is limited: the in vitro results use caffeine concentrations well above what a human normally reaches in their blood, as pointed out by participants. Although the study published in the 'Journal of Applied Physiology' suggests a mechanism for inhibiting protein synthesis, it constitutes preliminary mechanistic evidence, not clinical validation in humans. Current research (meta-analyses on caffeine and performance) largely confirms its role as an acute ergogenic aid, but chronic effects on hypertrophy remain debated and lack robust consensus. The community converges on the idea that context (dose, frequency, lifestyle) is determining and refuses to generalize these results to real-world weight training practice. In short, the direct extrapolation of these laboratory data to the human athlete is widely considered premature.

the sources

1. 1r/AdvancedFitness